Using a marginal P value of 0.05 in their MR results, the differential methylation appears to be a consequence of obesity rather than a cause for three other CpG sites: cg110244682 (SREBF1; P value = 4.1 × 10−3), cg17901584 (DHCR24; P value = 4.1 × 10−3) and cg26403843 (RNF145; P value = 0.011)8. The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.