Of these 28 CpG sites, 13 were identified by earlier EWAS studies of either T2D or related traits, including glucose, insulin, hemoglobin A1c (HbA1c), and homeostatic model assessment-insulin resistance (HOMA-IR)2–5,8,10,11 (Supplementary Table 1). The gene discussed is INS; the disease is type 2 diabetes mellitus.