Six of these meQTLs (4 cis and 2 trans-acting) are also associated with T2D, fasting glucose, fasting Insulin, or HbA1c in earlier studies21,22,27–29 and the directions of the effect between the SNP, methylation and glycemic traits are consistent (shown in Fig. 2 in the pink boxes, for details see Supplementary Table 4). This evidence concerns the gene INS and type 2 diabetes mellitus.