The prevalent simultaneously mutated gene was TP53, as identified in the only ovarian serous tumor sample also mutated in FBXW7 and PIK3CA (1/40, 2.5%); most of the colorectal tumors (86%) analyzed that were positive for mutations in FBXW7 had a concomitant mutation in KRAS [46]. Here, PIK3CA is linked to ovarian serous tumor.