LEPR and cancer: After combining all eligible case–control studies, we identified null relationship between rs1137101 polymorphism in LEPR gene and overall cancer risk under four genetic models (A vs. G: OR  =  0.97, 95% CI  =  0.89–1.06, P=0.547; AA vs. GG: OR  =  0.93, 95% CI  =  0.78–1.13, P =0.476; AA/GA vs. GG: OR  =  0.99, 95% CI  =  0.91–1.09, P=0.890 and AA vs. GA/GG: OR  = 0.92, 95% CI  =  0.82–1.04, P=0.198, Figures 2–5).