LEPR and cancer: After combining all eligible studies, we identified null relationship between LEPR gene rs1137101 G>A polymorphism and overall cancer risk [A vs. G: odds ratio (OR ) =  0.97, 95% confidence interval (CI ) =  0.89–1.06, P = 0.547; AA vs. GG: OR  =  0.93, 95% CI  =  0.78–1.13, P = 0.476; AA/GA vs. GG: OR  =  0.99, 95% CI  =  0.91–1.09, P= 0.890 and AA vs. GA/GG: OR  = 0.92, 95% CI  =  0.82–1.04, P= 0.198].