For the ethnicity of BC patients, the pooled sensitivity, specificity, DOR and AUC of RASSF1A methylation to diagnosis Caucasian were 0.54 (0.38–0.69), 0.96 (0.85–0.99), 30.0 (7.0–124.0) and 0.84 (0.81–0.87), while the pooled sensitivity, specificity, DOR and AUC of RASSF1A methylation to detect other ethnic groups (Africa and Asian) were 0.43 (0.24–0.64), 0.94 (0.86–0.98), 10.0 (2.0–51.0) and 0.81 (0.77–0.84), respectively. Here, RASSF1 is linked to breast cancer.