AKT1 and glioblastoma: Nguyen et al. showed that phosphorylation of STAT1 at serine 727 after IFNy stimulation is required for activation of PI3K and AKT in T98G glioblastoma cells [42], whereas Mounayar et al. reported a study on PI3Kα-dependent activation of STAT1 phosphorylation at serine 727, resulting in regulation of human mesenchymal stem cell immune polarization [43].