However, the exact role of autophagy activation induced by EGFR-TKIs remains an area of debate as some studies suggested that blocking autophagy improves the autitcancer activity of EGFR-TKIs to NSCLC cells [13, 14], whereas other studies proposed that induction of autophagy can lead to potentiation of inhibitory effect of EGFR-TKIs on NSCLC cells [16]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.