Since both EGFR-TKIs and curcumin induce autophagy in cancer cells, we infer that curcumin can enhance inhibitory effect of gefitinib on primary EGFR-TKI resistant NSCLC cells through augmenting gefitinib-induced autophagy and inducing autophagy-related cell death. This evidence concerns the gene EGFR and non-small cell lung carcinoma.