As show in Fig. 3a and b (right), in H157 cells, the inhibitory effect on the receptor tyrosine kinase induced by the two drug combination occurred at the transcriptional level, suggesting that combination of curcumin gefitinib remarkably suppress multiple receptor tyrosine kinase pathways in gefitinib-resistant NSCLC cells at both the transcriptional and protein levels. The gene discussed is NTRK1; the disease is non-small cell lung carcinoma.