EGFR and non-small cell lung carcinoma: We found that synergism of curcumin to gefitinib is more pronounced in gefitinib-resistant cells than in gefitinib-sensitive cells, and gefitinib induced lesser extent downregulation of EGFR activity in gefitinib-resistant cells compared to gefitinib-sensitive cells, suggesting that the insensitivity to gefitinib- induced downregulation of EGFR activity may be involved in gefitinib primary resistance in NSCLC cells, and curcumin reverse gefitinib resistance at least partially through suppressing EGFR activity.