The impact of CTLA-4 and PD-1 blockers on cancer research and their success in cancer treatment is acknowledged by researchers as well as clinicians worldwide and rightfully the Nobel Prize in Physiology or Medicine for 2018 was awarded to Professor James Allison, MD Anderson Cancer Center, USA and Professor Tasuku Honjo, Kyoto University, Japan for their research on CTLA-4 and PD-1 respectively [12]. The gene discussed is CTLA4; the disease is cancer.