In patients with tumor mutational burden of at least 10 mutations per megabase and PD-L1 expression of at least 1%, nivolumab monotherapy group in the study had lower median PFS (4.1 months) compared to nivolumab plus ipilimumab combination (7.1 months); HR for disease progression or death between combination group and monotherapy group was 0.75 [105]. The gene discussed is CD274; the disease is neoplasm.