We have previously shown that CRC patients have increased serum levels of IL-6, IL-7, IL-8, and platelet-derived growth factor BB (PDGF-BB), and the patients with distant metastasis have higher serum levels of IL-1ra, IL-4, IL-6, IL-7, IL-8, MCP-1, and PDGF-BB [22]. This evidence concerns the gene IL4 and colorectal carcinoma.