Furthermore, although overall fold-changes of p-AKT and p-p90RSK proteins were higher in ALS patients compared with controls, ALS#6 patient with a TDP-43 Q331K mutation had the highest level of p-AKT and downstream factor p-p90RSK but comparable levels of p-ERK1/2. The gene discussed is AKT1; the disease is amyotrophic lateral sclerosis.