Interestingly, in majority of ALS specimens with higher loss of monomeric TDP-43 and more aggregation (ALS #9 and #10) [8] showed significantly reduced RAB11 levels (Additional file 1: Figure S1), suggesting that impaired RAB11-mediated protein clearance may contribute to TDP-43 toxicity. The gene discussed is RAB11A; the disease is amyotrophic lateral sclerosis.