SSTR5 and laryngeal carcinoma: As shown in Fig. 3f, g, apparent methylation of exon 1 of SSTR5 and promoter of SSTR5-AS1 was detected in laryngeal carcinoma cells before 5-Aza-dC treatment and the methylation status was completely reversed after 5-Aza-dC treatment, suggesting the important role of exon 1 methylation of SSTR5 and promoter methylation of SSTR5-AS1 in gene silencing.