We first scanned relative expression level of SSTR5 in various tumor types in GEPIA dataset and found significant downregulation of SSTR5 in most of the tumor types including adrenocortical carcinoma (ACC), kidney renal clear cell carcinoma (KIRC), and pheochromocytoma and paraganglioma (PCPG) (Fig. 2B). The gene discussed is SSTR5; the disease is pheochromocytoma.