Recently, Reyes-Gibby et al. have reported that genetic variants in RP11-634B7.4 gene, which is annotated as antisense to the three olfactory receptor genes, OR13G1, OR6F1, and OR14A2, were significantly associated with severe pre-treatment pain among patients with head and neck cancer at genome-wide significance levels [39]. This evidence concerns the gene OR14A2 and head and neck cancer.