Excessive ROS can potentiate tumor progression and stimulate cell invasion through redox regulation of ROS-dependent pathways including the mitogen-activated protein kinase (MAPK) cascades, the phosphoinositide 3-kinase (PI3K) pathway, and nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway [22, 32–34]. This evidence concerns the gene WNK2 and neoplasm.