KRAS and cancer: This synergism is the result of both direct cancer cell toxicity by MEK-I, as evidenced especially in two KRAS mutated samples that were the most sensitive ones to MEK-I, and the immune-stimulatory effect of MEK-I on cytokine secretion profile of cancer cells and PBMCs with the induction of all cytokines that are able to sustain an immune-reactive and inflammatory micro-environment.