LCN2 and obesity due to melanocortin 4 receptor deficiency: Moreover, the conducted research showed that in type 2 diabetes with obesity there is a change in adipose tissue metabolism, expressed by the elevated plasma concentration of NGAL, in relation to the concentration of this regulatory molecule in plasma of subjects with metabolically healthy obesity, which can confirm the role of this adipocytokine in the pathomechanism of obesity leading to the development of insulin resistance, and consequently type 2 diabetes.