Two main assumptions have been made to resolve this issue: (1) HL of such patients could be caused by an uncertain impact of the GJB2 gene (the presence of yet undetected other pathogenic GJB2 variants or variable penetrance of pathogenic GJB2 variant due to any modulating factors); (2) these patients are only the coincidental carriers of one pathogenic GJB2 allele and other factors (other genes or environmental impacts) cause their HL. The gene discussed is GJB2; the disease is Hodgkins lymphoma.