In another study by the same group, HIF-1α was found to increase Gal-1 expression in colorectal cancer (CRC) cells, and the group identified two hypoxia-responsive elements upstream to the transcriptional start site of the Gal-1 gene that are essential for HIF-1-mediated galectin-1 expression [16]. Here, LGALS1 is linked to colorectal carcinoma.