Numerous studies have demonstrated the importance of the CCR2/CCL2 (MCP-1), CX3CR1/CX3CL1 (fractalkine), CXCR2/CXCL1, and CCR5/CCL2/CCL5 interactions in the progression of experimental atherosclerosis [108,109,110]. This evidence concerns the gene CCL2 and atherosclerosis.