Both compounds induced growth inhibition in human colon carcinoma HT-29 and LoVo cell lines (IC50 = 30 μM) by two types of interaction with DNA, namely covalent binding through the metal centre, in addition to an electrostatic non-covalent interaction in the case of 64 and intercalation for 65, besides the inhibition of thioredoxin reductase [89]. This evidence concerns the gene PRDX5 and colon carcinoma.