A related cationic N-heterocyclic carbene derivative to complexes 91a–d (complex 92) induced apoptosis in colon cancer cells HT-29 (IC50 = 3.44 μM) by inhibiting thioredoxin reductase and inducing an crucial imbalance in cellular redox homeostasis [109]. This evidence concerns the gene PRDX5 and colonic neoplasm.