PRDX5 and colonic neoplasm: An extended study on related alkynyl derivatives with para-substituted phenyl moieties and different phosphanes (complexes 109–117(a–d), Figure 8), has revealed an implication of electronic and steric factors in the antiproliferative activity against HT-29 colon cancer cells (IC50 values ranging from 0.1 to 6 μM) and for the inhibition of thioredoxin reductase activity [119].