Complexes with thiazolidine were the most active in murine colon carcinoma CT26-WT (IC50 = 1.8 μM for 54a and 0.9 μM for 54b), probably due to a faster ligand exchange process in the presence of the selenocysteine of the thioredoxin reductase [87]. Here, PRDX5 is linked to colon carcinoma.