In clinical manifestation, the odds ratio of GADD45b -712CT genotype with anti-RNP antibodies was 4.14 (95% CI, 1.10–15.63) in SLE patients, 11 out of 14 patients with anti-ribonucleoprotein (RNP) antibody were -712CT (Table 5). The gene discussed is RNPC3; the disease is systemic lupus erythematosus.