After combining Brailou’s results, Price proposed that the interaction of Nesfatin-1 and the G-protein coupled receptors in the hypothalamus could promote calcium ions influx and excite neurons to inhibit the feeding process of animals by enhancing the opening of L-type calcium channels or activating the PKA signaling pathway to reduce obesity. Here, NUCB2 is linked to obesity due to melanocortin 4 receptor deficiency.