KCNK3 and obesity due to melanocortin 4 receptor deficiency: By activating or knocking out the KCNK3 gene in mice, Yi Chen et al. [101] found that the potassium outflow caused by the activation of KCNK3 inhibited the calcium ions influx through VDCCs (voltage dependent calcium channels) and decreased the heat production of brown adipocyte cells to reduce obesity in mice—the result in knockout mice was the opposite.