PRRT2 and obesity due to melanocortin 4 receptor deficiency: Rya receptor channel can release calcium ions in ER/SR to regulate neuronal excitability to regulate the energy metabolism.The opening of voltage-dependent calcium channels can cause extracellular calcium ions influx into cells and regulate the effect of PKA to influence obesity.Wnt-Ca2+ signaling pathway can activate PKC and CaMK2 to reduce obesity through increasing intracellular calcium concentration.