CSPG4 and central nervous system cancer: Chondroitin sulfate proteoglycan 4 (CSPG4), formerly denoted as melanoma-associated chondroitin-sulfate proteoglycan (MCSP) or high-molecular-weight melanoma-associated antigen (HMW-MAA) is a heavily glycosylated transmembrane protein [13], which is overexpressed in a variety of prognostically unfavorable entities, such as melanoma [14], glioma [15], and triple-negative breast cancer [16].