CLOCK and chronic kidney disease: Detailed spatiotemporal dynamics of molecular clock activity in CKD kidneys was then tracked using explant cultures from a luciferase (LUC)-fusion protein based PER2 knock-in reporter strain (PER2::LUC; Yoo et al., 2004) sharing the same genetic background (C57/BL6J) as the wild type (WT) used in the other experiments of this study.