In addition, HOTAIR, p21, and p53 mRNA expression in doxorubicin- or γ rays-treated oral squamous cell carcinoma (OSCC) cells was up-regulated, indicating that the DNA damage response includes HOTAIR upregulation and may be closely connected to p53 and p21 expression and/or functionality [88]. The gene discussed is CDKN1A; the disease is oral cavity squamous cell carcinoma.