Deletions of either SLURP-1 or SLURP-2 leads to a mal de Meleda-like phenotype in mice and the combined double deficiency causes a comparable disease severity, as presented by the individual single deficiencies, suggesting that SLURP-1 and SLURP-2 either act together or act sequentially in the same pathway [49,50,51]. Here, SLURP2 is linked to mal de Meleda.