Regarding ALS, increased expression of several members of chemokines was found in CSF or blood from ALS patients than in controls or OND: C–C motif chemokine ligand (CCL)2, CCL3, CCL4, CCL11, C-X-C motif chemokine ligand (CXCL)8 and CXCL10; in addition, their levels also correlated with ALSFRS-R score or disease progression rate (DPR) [57,58,60,64,67,69,78,79,80] (Table 5). Here, CCL4 is linked to amyotrophic lateral sclerosis.