In attempts to reconcile these findings, it was demonstrated that there are distinct E-cadherin complexes at the AJs of polarized monolayers of the well-differentiated colon epithelial Caco2 cells: an apical-specific complex with tumor suppressing properties and a basolateral-specific that promotes pro-tumorigenic behavior, dependent on Src activity and Src-mediated p120 phosphorylation [16]. This evidence concerns the gene SRC and neoplasm.