Similarly, although E-cadherin loss was found to strongly predict lymph node-positive colorectal cancers [67], another study found no statistically significant correlation of reduced E-cadherin expression with development of metastatic colon disease [68] and loss of membranous expression of E-cadherin, which would indicate junction-bound cadherin was not significantly correlated to Duke’s staging, tumor grade, sex, size, and site of tumor [69]. Here, CDH1 is linked to neoplasm.