TNC and infectious otitis media: Based on the immunohistochemistry results showing that TNIIIA2-containing TNC peptides/fragments were localized within dysplastic lesions of AOM/DSS-treated mice, the effects of β1-integrin activation on human preneoplastic epithelial cell line HaCaT was investigated using peptide TNIIIA2 as a representative of TNIIIA2-containing TNC peptides/fragments.