CRC patients with high levels of circulating pro-inflammatory cytokines IL-6 and C reactive protein (CRP) showed higher risk of disease relapse in the DFS (HR= 5.6 [1.1-28.7], p=0.0368 for IL-6 and 2.2 [0.7-7.0], p=0.1682 for CRP, Table 2) and negative event in the EFS (HR= 5.4 [2.5-11.8], p<0.0001 for IL-6 and 4.6 [2.3-9.1], p<0.0001 for CRP, Table 3). Here, IL6 is linked to colorectal carcinoma.