VDAC1 at the OMM interacts with proteins that mediate and regulate the integration of signals generated elsewhere in the cell.6, 7, 8 VDAC1 also contributes to cancer cell metabolism via the binding and channelling of mitochondrial ATP directly to hexokinase (HK), the first enzyme in glycolysis, also highly expressed in various cancers.5 The gene discussed is VDAC1; the disease is cancer.