Staining of these same tissues with hematoxylin and eosin (H & E) revealed minimal multifocal hepatitis with signs of inflammation at 3 dpi, and moderate diffuse hepatitis with coagulative necrosis and extra medullary granulopoiesis in the liver of Ifnar1-/- mice (S1 Fig). The gene discussed is IFNAR1; the disease is hepatitis A virus infection.