Paradoxically, Myd88-deficient mice, are not only highly susceptible to parasite infection, but cannot be rescued with exogenous administration of IL-12, strongly suggesting that signaling from both IL-12 and the inflammasome-mediated cytokines IL-1β and IL-18 are required for host resistance against T. gondii [10]. This evidence concerns the gene MYD88 and parasitic infectious disease.