Furthermore, some clones were equally resistant to bnAbs targeting other Env sites,such as V1V2, V3-glycan, subunit interface, fusion peptide and MPER (Table 1).It should be noted that these clones were derived from patients with both acute (BJOX2000) and chronic (CNE6, CNE23, CNE63, CNE64, CNE66, BL01, TV1.29 and TZA125.17) infection, and none of them received any intervention related to bnAbs.Notably, among the previously published non-Chinese clones, all except X2088.c9 were isolated during acute or early infection (Table 1, right panel). This evidence concerns the gene C9 and infection.