As a consequence of ZEB1 insufficiency, various epithelial-like features are observed in PPCD corneal endothelium, including a stratified organization, desmosomal intracellular junctions, and expression of an epithelial-like transcriptomic profile, including increased/ectopic expression of epithelial-associated keratins and cadherins (e.g., CDH1), and decreased expression of CDH2 [15, 20, 21]. The gene discussed is ZEB1; the disease is posterior polymorphous corneal dystrophy.