Recently we reported that reduced ZEB1 expression in a cell-based model of PPCD using short-interfering RNA (siRNA) targeting ZEB1 resulted in significantly increased CEnC apoptosis and barrier function [21], consistent with prior reports of ZEB1 reduction leading to increased cell death [22, 23] and increased cell barrier function [24–26]. The gene discussed is ZEB1; the disease is posterior polymorphous corneal dystrophy.