Herein, we validated the ZEB1 monoallelic knockout cell line as a cell-based model of PPCD using a transcriptomics approach, and provide evidence (transcriptomic and cell function) to support our hypothesis that a novel MET-like process, termed endothelial to epithelial transition (EnET), best explains the PPCD phenotype. The gene discussed is ZEB1; the disease is posterior polymorphous corneal dystrophy.