IRF4 and skin neoplasm: These six underlying loci (HERC2 [MIM 605837] /OCA2 [MIM 611409], IRF4 [MIM 601900], MC1R [MIM 155555], RALY [MIM 614663], SLC45A2 [MIM 606202] and TYR [MIM 606933]) were previously found to be associated not only with skin cancer traits, but also with pigmentation traits of skin, eyes and hair (Fig 2; MIM 266300) [31, 49–68].