After the onset of unilateral ureteral obstruction, IL-10 knockout mice show increased infiltration of inflammatory cells and cytokines, including monocyte chemoattractant protein-1, TNF-α, IL-6, IL-8, RANTES, or macrophage colony-stimulating factor, in the kidney compared with WT controls [42]. The gene discussed is TNF; the disease is Ureteral obstruction.