ROBO1 and preeclampsia: SLIT2 and ROBO1 encode proteins of the SLT2-ROBO1 signaling pathway; previous studies have indicated that this pathway is associated with different types of pregnancy complications, including preeclampsia [27,28], impaired placentation of missed and threatened miscarriage in early pregnancy [29], trophoblast invasion, and vascular remodeling during ectopic tubal pregnancy [29,30].