TNF and infection: In contrast, mice treated with a low dose (1 mg/kg) or high dose (10 mg/kg) of Infliximab showed 100% lethality within 7 days similar to Listeria-challenged TNFKO mice, indicating that the systemic blockage of TNFα by Infliximab destroys the TNF-dependent host defense mechanism and aggravates infection of Listeria in the host.