We previously reported an association between MetS and differential DNA methylation in the ABCG1 gene involved in cellular cholesterol transport and found to be altered in approximately 35% of breast cancer cases.35 The current study will provide critical epidemiologic and clinical data on a wide range of novel and established breast cancer risk factors that can serve as a basis for future investigations into determinants of breast cancer risk and survival among African women in Nigeria. The gene discussed is ABCG1; the disease is breast carcinoma.