Hence, a new agent with lower hepatotoxicity and higher effect derived from geldanamycin, 17-DMCHAG, inhibited the proliferation and colony formation of human PCa cell lines and also showed strong anticancer effects in xenograft nude mice via Hsp90 repression, as manifested by the upregulation of E-cadherin and downregulation of vimentin.33 This evidence concerns the gene CDH1 and posterior cortical atrophy.