Simvastatin23 and metformin24, 25 displayed inhibition of mesenchymal markers such as N-cadherin and vimentin as well as upregulation of E-cadherin in PCa cells, contributing to a blockade of transforming growth factor beta 1 (TGF-β1)-induced EMT. This evidence concerns the gene TGFB1 and posterior cortical atrophy.