In most cancers, E-cadherin expression is downregulated due to promoter methylation, causing the tumor progression and metastasis.13, 14, 15 Src tyrosine kinase-mediated phosphorylation, as a major post-translational mechanism of E-cadherin level, induces the ubiquitination of E-cadherin and EMT occurrence.16 This evidence concerns the gene CDH1 and cancer.