For instance, mTOR activity was found to decrease upon administration of neurotoxins that causes permanent symptoms of PD such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,36-tetrahydropyridine (MPTP) and rotenone (Chen et al., 2010, Rieker et al., 2011, Rodriguez-Blanco et al., 2012, Selvaraj et al., 2012, Xu et al., 2014, Zhou et al., 2015). This evidence concerns the gene MTOR and Parkinson disease.