The mean tissue level of SOD was significantly decreased in AFB1 induced HCC group compared to the control group, P value was < 0.0001, the mean tissue level of SOD was significantly increased in C. Sempervirens 300, 600, P. Ginseng 250, 500, N. Sativa 500, 1000 and silymarin groups compared to AFB1 induced HCC group (P value < 0.0001). This evidence concerns the gene SOD1 and hepatocellular carcinoma.