LGR6 and clear cell adenocarcinoma: As shown in Figures 2A–2C, LGR6 expression levels were robustly and significantly upregulated in different histologic types of ovarian cancer, including serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, and clear-cell adenocarcinoma, compared with those in normal ovarian epithelial tissues, particularly in high-grade serous adenocarcinoma, and high expression of LGR6 was detected in 153/294 ovarian cancer tissues (52.0%).