STAT3 and ovarian cancer: has found that STAT3 was found to be hyperactivated in ovarian cancer spheroids, where activity of Wnt/β-catenin was indispensable for STAT3-induced or maintained stemness in ovarian cancer cells; moreover, Mariya and colleagues16 have reported that MMP10 promoted stemness and chemotherapeutic resistance of ovarian cancer stem-like cells by activating Wnt/β-catenin signaling.