has reported that an apoptosis-enhancing drug, birinapant, aimed at eliminating the CSC subpopulation in ovarian cancer, re-sensitized ovarian cancer cells to carboplatin via cleavage of caspase 8 and restoration of apoptosis caused by degradation of baculoviral IAP repeat containing 3 (cIAP). The gene discussed is BIRC3; the disease is ovarian carcinoma.