In LGR6-silenced ovarian cancer cells, S33Y, which was used to constitutively activate Wnt/β-catenin signaling as a mutant-β-catenin (serine 33 to tyrosine),27 was further transfected to investigate the functional role of Wnt/β-catenin signaling in the regulatory functions of LGR6 in stemness and chemoresistance in ovarian cancer cells. This evidence concerns the gene LGR6 and ovarian cancer.