A recent research suggested a crosstalk between BDNF, Wnt/β-catenin and Shh signaling in chronic unpredictable mild stress (CUMS) induced prenatal stress and reported that the BDNF, β-catenin and Shh downregulates in depression and also decreases hippocampal neurogenesis [24]. The gene discussed is BDNF; the disease is depressive disorder.