RAMP2 and metabolic dysfunction-associated steatohepatitis: In an earlier study (Heliyon 2017), we developed a mouse NASH model by feeding the mice a methione- and choline-deficient (MCD) diet with high-salt loading (8% NaCl in the drinking water) for 5 weeks in heterozygous RAMP2 knockout mice (RAMP2+/−) [15].