MTHFR and lung cancer: The results from a previous meta-analysis revealed a significant association between the MTHFR C677T polymorphism and an increased risk of lung cancer in Asian populations; however, the study did not find a significant association of the MTHFR A1298C polymorphism with susceptibility to lung cancer in Asians.[13,14] Two meta-analyses[15,16] were carried out to assess the association between MTHFR gene polymorphisms and lung cancer risk in Chinese people and draw a consistent conclusion.