The most commonly prescribed herbal formula, Jia-Wei- Xiao-Yao-San, has been used for thousands of years to treat women's disorder ranging from menstrual problems, infertility to menopausal syndromes.[15] It had been demonstrated that this prescription could be used for women who are prone to mood disorders and anxiety.[16] Jia-Wei-Xiao-Yao-San had also been found to increase levels of tumor necrosis factor-α,[17] which might affect mood and emotional status. Here, TNF is linked to mood disorder.