INS and coronary atherosclerosis: TyG index is a useful surrogate marker for insulin resistance,[25] which is independently associated with the presence of coronary artery atherosclerosis;[29] notably, this parameter was recently shown to be an important risk factor for IHD.[30,31] Insulin resistance leads to a relative reduction of insulin action, then to hyperglycemia and consequently to higher production of insulin by pancreatic β-cells.