STX1A and myocardial ischemia: Notably, even if our results will need to be replicated in larger cohorts of IHD patients, they are consistent with evidence reported by an important Genome-Wide Association study (GWAS), which showed a strong association of 7q11 region with Triglyceride alterations.[41]Stx-1A maps in a region 70kb close to one of the genes suggested by GWAS: that is MLX-interacting protein-like (MLXIPL), significantly associated with Coronary heart disease.[42] An in-depth evaluation of the Stx-1A SNPs influence in cardiologic risk is warranted to confirm the involvement of these SNPs in IHD.