Evidence here reported leads to assume a putative role of Stx-1A rs4717806 in IHD, possibly due to its influence in insulin-dependent glucose metabolism and therefore also in altered lipids pathways, which are well-known risk factors for cardiovascular disease.[40] We cannot nevertheless exclude that the correlation of Stx-1A with IHD is the effect of a lower efficacy of KATP channel, resulting in higher risk for atherosclerosis.[11]. Here, STX1A is linked to myocardial ischemia.