IL10 and infection: Whilst Firmino-Cruz et al. (16) showed that B cells are related with lesion pathogenesis through the production of antibodies and IL-10 during L. amazonensis infection in BALB/c mice (27) showed that B cell-deficient JHD mice infected with L. amazonensis show a significantly reduced lesion compared to wild-type mice, suggesting that B cells promote exacerbation of the infection, and that antibodies may contribute to immunopathology.