CD8A and renal cell carcinoma: Primary studies on RCC showed that PD-1 expression on immune cells was associated with a poor clinical outcome (27) and infiltration of intratumoral PD-1+ T cells was an independent adverse predictor of survival (28), whereas our study observed that CD8+PD-1IM+, which had a negative effect on survival in RCC, remained in the neo-IS due to its correlation with CD8+PD-1CT+ (Figure 4D).Its role may be due to the inhibition of tumor immunity by PD-1+CD8IM+ immune cells (29).