CD8A and cancer: In 2007, “immune contexture” including subtypes (CD3+CD8+, CD3+CD45RO+), functional orientation (Th1 cell-associated factors, cytotoxic factors, chemokines, cytokines, and adhesion molecules), density and location [tumor center [CT], invasive margin [IM] and the quality of tertiary lymphoid structures [TLS]] of immune infiltrating cells, were reviewed to show the important role of the immune system and a superior prognostic factor in cancers (5).