CD8A and cancer: Due to the high background staining and loss of antigenicity of CD45RO and GZMB, Galon and other researchers proposed the use of two easy membrane stains, CD3 and CD8, both in CT and IM in the IS system proposed by the Society for Immunotherapy of Cancer (SITC) to initiate a task force to validate its use in standard clinical practice as a new approach for the classification of tumors (7).