In the present study, we incorporated TAM, Treg and its co-inhibitory molecules, CD8 or CD68 coexpressing PD-1 or IDO, CD3 coexpressing PD-L1 to build a novel immune feature-based score to predict the OS of RCC patients after nephrectomy and compared this new model to the IS proposed by the SITC. This evidence concerns the gene CD68 and renal cell carcinoma.