In support for the central role of LSD1 in AML, pharmacological inhibition of LSD1 with GSK-LSD1 and ORY-1001, both of which irreversibly inactivate the enzyme, leads to significant reduction in proliferation of various AML tissue culture lines and increase in survival of murine disease models (64, 65). Here, KDM1A is linked to acute myeloid leukemia.